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Year : 2022  |  Volume : 12  |  Issue : 1  |  Page : 10-13

Prevalence of Mycobacterium tuberculosis in patients suffering from chronic respiratory diseases in a tertiary care hospital using Gene Xpert as the diagnostic tool

1 Intermediate Reference Laboratory, Guwahati, Assam, India
2 Department of Microbiology, Gauhati Medical College and Hospital, Guwahati, Assam, India

Correspondence Address:
Dina Raja
Department of Microbiology, Gauhati Medical College and Hospital, Narakasur Hilltop, Bhangagarh, Guwahati 781032, Assam
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/ajoim.ajoim_3_21

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Background: Chronic respiratory diseases constitute a grave problem throughout the world and particularly in the middle- and low-income countries. The burden of these diseases leads to poor quality of life and disability of affected individuals leading to premature deaths and a great economic loss to their families and society. Tuberculosis remains one of the deadliest communicable diseases. Though culture is the gold standard for the diagnosis of tuberculosis, the long period of time required for a positive result leads to the transmission of the disease in the community. Objective: The study was conducted to study the prevalence of Mycobacterium tuberculosis in patients suffering from chronic respiratory diseases. Materials and Methods: Bronchoalveolar lavage fluid samples of patients with chronic respiratory diseases undergoing bronchoscopy were collected under aseptic conditions after obtaining approval from the Institutional Ethics Committee. Each sample was subjected to Ziehl Neelsen stain and Cartridge Based Nucleic Acid Amplification Test (CBNAAT) on Xpert MTB/RIF manufactured by Cepheid (Sunnyvale, CA). Results: Eighteen of 110 cases (16.36%) showed the presence of M. tuberculosis in the samples, of which rifampicin resistance was detected in 2 (11.11%) cases. Conclusions: M. tuberculosis remains a common underlying pathogen in the cases of chronic respiratory diseases.

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